Molecular basis of circadian rhythmicity in renal physiology and pathophysiology
نویسندگان
چکیده
منابع مشابه
Molecular bases of circadian rhythmicity in renal physiology and pathology.
The physiological processes that maintain body homeostasis oscillate during the day. Diurnal changes characterize kidney functions, comprising regulation of hydro-electrolytic and acid-base balance, reabsorption of small solutes and hormone production. Renal physiology is characterized by 24-h periodicity and contributes to circadian variability of blood pressure levels, related as well to nych...
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The discovery of aquaporin-1 (AQP1) by Agre and associates answered the longstanding biophysical question of how water specifically crosses biological membranes. In the kidney at least 7 aquaporins are expressed at distinct sites. AQP1 is extremely abundant in the proximal tubule and descending thin limb and is essential for urinary concentration. AQP2 is exclusively expressed in the principal ...
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The temperature compensated in vitro oscillation of cyanobacterial KaiC phosphorylation, the first example of a thermodynamically closed system showing circadian rhythmicity, only involves the three Kai proteins (KaiA, KaiB, and KaiC) and ATP. In this paper, we describe a model in which the KaiA- and KaiB-assisted autocatalytic phosphorylation and dephosphorylation of KaiC are the source for ci...
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the six bilayer spanning domains are connected by five Introduction loops (A–E in Figure 1). The molecule consists of two repeats of three a-helices which are 180° mirror images An essential function of the mammalian kidney is its of each other (Figure 1). Each repeat contains the ability to conserve or excrete free water independent highly conserved family characteristic asparagineof changes i...
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ژورنال
عنوان ژورنال: Experimental Physiology
سال: 2016
ISSN: 0958-0670
DOI: 10.1113/ep085781